1. Start

A review on the role of GHET1 in different cancers

Zugehörigkeit
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ghafouri-Fard, Soudeh;
Zugehörigkeit
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ahmadi Teshnizi, Sara;
Zugehörigkeit
Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq
Hussen, Bashdar Mahmud;
GND
1249707153
ORCID
0000-0001-8381-0591
Zugehörigkeit
Institute of Human Genetics, Jena University Hospital, Jena, Germany
Taheri, Mohammad;
Zugehörigkeit
Proteomics Research Center, Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Zali, Hakimeh

Gastric cancer High Expressed Transcript 1 (GHET1) is an RNA gene located on chromosome 7q36.1. This non-coding RNA is involved in the pathology of different cancers. It can regulate cell proliferation, apoptosis and cell cycle transition. Moreover, it induces epithelial-mesenchymal transition. Up-regulation of GHET1 has been correlated with poor prognosis of patients with different malignancies. Besides, its up-regulation has been mostly detected in later stages and advanced grades of cancers. This review summarizes recent studies on the expression of GHET1, its in vitro functions, and its impact on the beginning and progression of cancer based on xenograft models of cancer.

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Einordnung

Erschienen in:
Pathology, research and practice
Bd. 247 (07.2023)Art.-Nr.:154545
Band:
247
Datum der Veröffentlichung:
07.2023
URN:
urn:nbn:de:gbv:27-dbt-20240327-124531-000
DOI:
10.1016/j.prp.2023.154545
Sonstiger Identifikator (pubmed):
37244053
Sprache:
Englisch
Ressourcentyp:
Text
Umfang:
7 Seiten
Verlag:
Elsevier BV
Schlagwörter:
Cell Line, Tumor; Humans; Neoplasms; Prognosis; Cell Cycle; Cell Proliferation; Cell Movement; Gene Expression Regulation, Neoplastic; Epithelial-Mesenchymal Transition; RNA, Long Noncoding; Biomarkers, Tumor; Cancer; Expression; Biomarker; Lncrna; Ghet1
DDC-Sachgruppe der DNB:
610 Medizin, Gesundheit
Einrichtung:
Friedrich-Schiller-Universität Jena, Medizinische Fakultät
Anmerkung:
Zweitveröffentlichung

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