The paper focuses on two fundamental concepts of 20th century life sciences: Homeostasis and Umwelt. Both concepts describe the reciprocal relationship between organisms and their surroundings and are based on a holistic conception of the body. The paper examines on the one hand the linkage of past, present, and future knowledge of the body in both concepts starting from Aby Warburg’s time model of Nachleben. On the other hand, the historicity of knowledge is reflected by confronting Warburg’s Nachleben with Georges Canguilhem’s history of concepts. Finally, the historical analysis of the two concepts reveals the conditions of possibility for a linkage of the two concepts in the 1970s and thus contributes to the history of holistic body knowledge.