For high-throughput screening of genetically modified plant cells, a system for the automatic analysis of huge collections of microscope images is needed to decide whether the cells are infected with fungi or not. To study the potential of feature based classification for this application, we compare different classifiers (kNN, SVM, MLP, LVQ) combined with several feature reduction techniques (PCA, LDA, Mutual Information, Fisher Discriminant Ratio, Recursive Feature Elimination). We achieve a significantly higher classification accuracy using a reduced feature vector instead of the full length feature vector.